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Post Doctoral Fellow, Research Institute

Job ID CPMC-2116791 Date Posted 11/01/2021 Location San Francisco, California Schedule/Shift Full Time/ Day
Position Overview:

Location

San Francisco, California

Discipline

Science/R&DCell Biology, ChemistryGenomics, Molecular Biology, Cancer BiologyPharmacology

Required Education

Doctorate/PhD

Position Type

Full time

JOB SUMMARY:

The California Pacific Medical Center Research Institute is a dynamic group of scientists and clinical investigators focused on biomedical, clinical and translational research. We are the research component of California Pacific Medical Center, the largest medical center in San Francisco. Currently we are seeking a self-motivated, innovative and independent scientist to join our laboratory, whose focus is the identification of novel markers and mediators of cancer progression, and the development of novel targeted therapies for cancer, with a principal focus on melanoma. To date, our laboratory has assigned pro-metastatic function to several genes in melanoma and other cancers, including NCOA3, BPTF, and PARP1 (see references below). Ongoing work is attempting to further develop several of these as therapeutic targets. In addition, we are investigating therapy resistant melanoma brain metastasis, with the goal of discovering combination drug treatments to target this aggressive form of melanoma. The successful candidate will work with our faculty members in the CPMCRI Precision Medicine Program (termed the Cancer Avatar Project).

This position requires advanced knowledge of rodent (mouse) surgical procedures, and primary mammalian cell culture. Good working knowledge of cancer biology, biochemistry, molecular and cell biology are required. Previous publications in the field of cancer research are highly desirable. Knowledge of handling of human tissues and blood and prior experience in animal models of cancer (xenograft) is required. In addition,hands on experience with immune oncology mouse models, cancer genomics and pharmacogenomics are highly desirable. PhD with less than 2 years postdoctoral experience preferred. Supervision will be provided jointly by CPMCRI senior scientists affiliated with the Avatar program. Must be highly collaborative, team-oriented, but also capable of working independently. Strong written/verbal communication skills are required. The position may require occasional weekend and evening duties. Salary is commensurate with experience.

You can learn more about our research projects here:

  1. Ice R.J, Chen M, Sidorov M, Le Ho T, Woo R, Rodriguez-Brotos A, Luu T, Jian D, Kim KB, Kim A, Stone D, Nazarian A, Oh A, Tranah GJ, Nosrati M, De Semir D, Dar A, Chang S, Desprez PY, Kashani-Sabet M, Soroceanu L, McAllister SD

Drug responses are conserved across patient derived xenograft models of melanoma leading to identification of novel drug combination therapies. Br. J Cancer. 2020, Mar: 122 (5):648-657. PMCID: 7954294.

  1. Kim KB, Soroceanu L, De Semir D, Millis SZ, Ross J, Vosoughi E, Dar AA, Nosrati M, Desprez PY, Ice R, Chen M, Chetal K, Bhattacharjee, Moretto J, Leong SP, Singer MI, Parrett BM, Minor DR, McAllister SD, Kashani-Sabet M. Prevalence of homologous recombination pathway gene mutations in melanoma: rationale for a new targeted therapeutic approach. Journal of Investigative Dermatology, Vol 141, 8, Aug 2021:2028-2036. PMID:33610559.
  2. De SemirD, BezrookoveV, NosratiM, DarAA, Miller JR III, LeongSP, KimKB, LiaoW, SoroceanuL, McAllisterS, DebsRJ, SchadendorfD, LeachmanSA, CleaverJE, Kashani-Sabet M. Nuclear receptor coactivator NCOA3 regulates ultraviolet radiation-induced DNA damage and melanoma susceptibility. Cancer Research. 2021 Mar 25. Online ahead of print.
  3. Dar AA, NosratiM, Bezrookove V, de Semir D, Majid S, Thummala S, SunV, Tong S, Leong SPL, Minor D, Billings PR, Soroceanu L, Debs R, Miller JR III, Sagebiel RW, Kashani-Sabet, M. The role of BPTF in melanoma progression and in response to BRAF-targeted therapy. J Natl Cancer Inst, 2015 Feb 23; 107(5). Pii: djv034. Doi:10.1093/jnci/djc034. PMID: 25713167; PMC4555639


Qualifications:

Education:

Doctoral degree in Biology or related field required (Doctorate, PhD).

Experience:

  • At least 1 year of experience working in basic or translational research is required.
  • Experience in designing research studies is desired.
  • Areas of interest: cancer biology, genomics, pharmacology, targeted therapy, cancer biomarkers.

Knowledge:

  • Strong interest and background in basic laboratory research;
  • Familiar with routine cell culture techniques required for cancer biology studies.
  • Familiar with in vivo studies using xenografts models of human malignancy.

Skills:

  • Ability to prepare manuscripts for publication.
  • Facility with Microsoft Word, Excel, PowerPoint, and Adobe software.
  • Able to assist with preparation of grant applications.


Organization:California Pacific Medical Center
Employee Status: Regular
Employee Referral Bonus: No
Benefits: Yes
Position Status: Exempt
Union: No
Job Shift: Day
Shift Hours:8 Hour Shift
Days of the Week Scheduled:Monday-Friday
Weekend Requirements: None
Schedule: Full Time
Hrs Per 2wk Pay Period:80
Applications Accepted:All Applications Accepted

Sutter Health Affiliates are equal opportunity employers EOE/M/F/Disability/Veterans

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